Congenital Malformations Induced in Rats by Maternal Vitamin A Deficiency
- 1 January 1948
- journal article
- research article
- Published by Elsevier in Journal of Nutrition
- Vol. 35 (1) , 1-11
- https://doi.org/10.1093/jn/35.1.1
Abstract
Congenital abnormalities can be induced in the offspring of female rats reared and bred on diets deficient in vitamin A. The abnormalities are found in soft tissues and are different from those induced in the skeleton by maternal riboflavin deficiency. Variations of the preparatory diet influence the yield of abnormal young. Increase of the carotene supplement results in an increased fertility rate, but the percentage of abnormal young decreases. Reduction of the carotene supplements reduces fertility while the percentage of abnormal young increases.Keywords
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