Genetic control of a shared idiotype among antibodies directed to distinct specificities.

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Abstract
An idiotypic radioimmunoassay system was developed to detect shared idiotypic determinants, termed GTGL idiotype, on antibodies bearing distinct antigen-binding specificities in various mouse strains. Poly-(Glu, Tyr) (GT)- or poly-(Glu, Lys) (GL)-related determinants can induce anti-GT and anti-GL (GTGL)-idiotypic antibodies. Strain distribution studies indicate that GTGL-idiotypic antibodies are readily induced and frequently expressed in antisera obtained from 25 different mouse strains immunized with GT-related or GL-related polymers. The ability to express GTGL-idiotypic antibodies is a dominant trait and is controlled by Igh[immunoglobulin heavy chain]-linked gene(s). In anticopolymer of L-glutamine acid60-L-alanine30-L-tyrosine (GAT) and anticopolymer of L-glutamic acid54-L-lysine35-L-phenylalanine11 (GL.vphi.) antisera, antibodies uniquely specific to GAT or GL.vphi., respectively, and antibodies bearing dual specificities for GAT and GL.vphi., expressed GTGL idiotype. The genetic implications of these findings are discussed.

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