PHARMACOKINETICS OF NAPROXEN IN HEALTHY-VOLUNTEERS AND IN PATIENTS WITH DIABETIC MICROANGIOPATHY

  • 1 January 1979
    • journal article
    • research article
    • Vol. 17  (12) , 486-491
Abstract
The pharmacokinetics of Naproxen, an antiinflammatory drug with antipyretic and analgesic actions, administered as a single oral dose of 250 mg, was determined in 7 healthy volunteers and 9 patients who were diagnosed as suffering from diabetes mellitus with varying degrees of angiopathy. A 2 compartment model was used to described the biphasic decline in serum concentration and to calculate the amount of drug in the central and peripheral compartments. Values were obtained for various pharmacokinetic parameters. In patients with severe diabetic microangiopathy, a decrease may be seen in the fraction of the dose absorbed shown by a decrease in the Cmax [serum peak] and the (AUC, area under the curve) 0-8 h. The glomerular impairment of some patients leads to a decrease in the elimination constant.

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