Effect of Lovastatin on Cholesterol Absorption in Cholesterol-Fed Rabbits
- 1 March 1993
- journal article
- Published by Wiley in Basic & Clinical Pharmacology & Toxicology
- Vol. 72 (3) , 148-151
- https://doi.org/10.1111/j.1600-0773.1993.tb00307.x
Abstract
The aim of the present study was to investigate the effect of the hydroxymethylglutaryl (HMG)-CoA reductase inhibitor lovastatin on some aspects of cholesterol metabolism in cholesterol-fed rabbits. The plasma cholesterol concentration was markedly lower in lovastatin-treated rabbits (6 mg/rabbit/day) compared to controls after 36 days of cholesterol-feeding (x +/- S.E.) (19 +/- 4 mmol/l, n = 9 versus 153 +/- 17 mmol/l, n = 7) (P < 0.00001). Intestinal absorption of cholesterol in such rabbits was reduced by 15% in lovastatin-treated rabbits (n = 21) compared to controls (n = 18) (P < 0.025). The results suggest that the hypocholesterolaemic effect of lovastatin in cholesterol-fed rabbits is associated with a decreased intestinal absorption of cholesterol.Keywords
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