Alteration of Blood on Storage: Measurement of Adhesiveness of Aging Platelets and Leukocytes and Their Removal by Filtration

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Abstract
DURING studies of blood viscosity with a method designed to determine resistance to flow in very small blood vessels, it was unexpectedly found that very high pressures became necessary to force blood-bank blood through a microfilter with multiple openings 20 microns square after storage in acid-citrate-dextrose (A.C.D.) solution for two to ten days or longer or in heparin for only one day. This phenomenon, the apparatus that demonstrated it and a method by which the filtration characteristics of old stored blood can be returned to normal are described below.Material and MethodsBlood was routinely collected in A.C.D. solution or . . .

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