FURTHER OBSERVATIONS ON INTERFERENCE BETWEEN LYMPHOCYTIC CHORIOMENINGITIS AND MM VIRUSES

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Abstract
Well marked interference is demonstrable when LCM virus is injected cerebrally in hamsters and MM virus peritoneally four or seven days later, the usual paralyzing action of the latter virus being prevented. This interference can still be demonstrated when the MM virus is injected 30 days after the LCM virus, but not when the sequence of the injections is reversed. The unparalyzed survivors of a successful interference experiment are actively immune to LCM virus. The brain, cord, and viscera of survivors, tested 10 and 11 days after the beginning of an interference experiment, contain the same amount of LCM virus as the organs of controls inoculated with this virus alone. The same organs, however, contain significantly less MM virus than the organs of controls inoculated with MM virus only. It appears that in a successful interference experiment, MM virus is prevented from multiplying in the organs of the hamster for at least six or seven days. Observations on the distribution of LCM and MM viruses in the viscera, brain, and cord of normal hamsters show that in both instances the blood is quickly invaded, and thereafter viral growth occurs in the viscera as well as the central nervous system. The reaction between the two viruses probably therefore occurs in viscera as well as central nervous system.

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