Quantitative Studies of Iodide Excretion in Saliva in Euthyroid, Hypothyroid and Thyrotoxic Patients

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Abstract
The amount of iodide excreted in the parotid and submandibular saliva in unit time has been compared to the amount taken up by the thyroid gland (absolute iodine uptake or AIU) in 21 euthyroid, 24 thyrotoxicand 12 hypothyroid patients. Although the AIU was found to be high in thyrotoxicosis and low in hypothyroidism, no such differences were found in the salivary iodide excreted. It is concluded that the iodide concentrating mechanism in the salivary glands is independent of thyroid function. More iodide is excreted in parotid than in the submandibular saliva. In euthyroid patients almost as much iodide is excreted in the saliva as is taken up by the thyroid gland.

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