Oral Immunization with an rfaH Mutant Elicits Protection against Salmonellosis in Mice
Open Access
- 1 July 2004
- journal article
- research article
- Published by American Society for Microbiology in Infection and Immunity
- Vol. 72 (7) , 4297-4301
- https://doi.org/10.1128/iai.72.7.4297-4301.2004
Abstract
Loss of the transcriptional antiterminator RfaH results in virulence attenuation (>10 4 -fold increase in 50% lethal dose) of the archetypal Salmonella enterica serovar Typhimurium strain SL1344 by both orogastric and intraperitoneal routes of infection in BALB/c mice. Oral immunization with the mutant efficiently protects mice against a subsequent oral infection with the wild-type strain. Interestingly, in vitro immunoreactivity is not confined to strain SL1344; rather, it is directed also towards other serovars of S. enterica and even Salmonella bongori strains.Keywords
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