Systemic Lupus Erythematosus with Deficiency of the T4 Epitope on T4 Helper/Inducer Cells
- 12 December 1985
- journal article
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 313 (24) , 1544-1545
- https://doi.org/10.1056/nejm198512123132414
Abstract
To the Editor: Stohl et al. (June 27 issue) contend that the altered T4 phenotype in their three patients with systemic lupus erythematosus (SLE) accounted for the impaired helper/inducer-cell function of blood lymphocytes in vitro.1 However, they present no formal evidence to support this claim. Peripheral-blood mononuclear cells from the three probands were clearly deficient in their capacity to generate immunoglobulin-secreting cells when stimulated with the polyclonal B-cell activator pokeweed mitogen. As previously reported,2 this finding is a general characteristic of cells from patients with SLE who have phenotypes with the T4 epitope intact. Therefore, the authors focused on the . . .Keywords
This publication has 8 references indexed in Scilit:
- Perturbation of the T4 molecule transmits a negative signal to T cells.The Journal of Experimental Medicine, 1985
- Absence of the OKT4 epitope on blood T cells and thymus cells in a patient with thymoma, hypogammaglobulinemia, and red blood cell aplasiaJournal of Allergy and Clinical Immunology, 1985
- Systemic Lupus Erythematosus with Deficiency of the T4 Epitope on T Helper/Inducer CellsNew England Journal of Medicine, 1985
- Heterogeneity in Expression of the T4 Epitope in Black IndividualsScandinavian Journal of Immunology, 1984
- FAMILIAL OKT4+ LYMPHOCYTE DEFICIENCYThe Lancet, 1984
- Absence of OKT4-positive lymphocytes in black African subjectsCellular Immunology, 1984
- Antigenic polymorphism of the T4 differentiation antigen expressed on human T helper/inducer lymphocytesHuman Immunology, 1984
- Five epitopes of a differentiation antigen on human inducer T cells distinguished by monoclonal antibodiesCellular Immunology, 1983