EFFECT OF CHEMOTACTIC FACTORS AND AGENTS WHICH INFLUENCE NEUTROPHIL MOVEMENT ON ANAEROBIC GLYCOLYSIS AND HEXOSE MONOPHOSPHATE SHUNT ACTIVITY

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  • 1 January 1978
    • journal article
    • research article
    • Vol. 35  (1) , 141-149
Abstract
The effects were assessed of 2 chemotactic factors, endotoxin activated serum (EAS) and casein and a number of drugs known to affect intracellular cyclic nucleotide levels and various forms of neutrophil movement, on [human] neutrophil anaerobic glycolysis and hexose monophosphate shunt (HMPS) activity. EAS caused stimulation of glycolysis, HMPS activity and NBT [nitroblue tetrazolium] reduction. Casein was without effect on glycolysis and NBT reduction and inhibited HMPS activity. Drugs known to increase intracellular c[cyclic]AMP levels caused a depression of HMPS activity; those reported to elevate cGMP had a variety of effects. Glycolysis was not affected by any of these agents. A lack of relationship between cyclic nucleotide effects on cell motility and neutrophil glycolysis and HMPS activity is indicated.