Influence of osmotic pressure and viscosity on intestinal drug absorption. II. Quinine concentration profile in plasma after oral administration of various quinine solutions to rats.

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Abstract
The effects of osmotic pressure and viscosity were examined on the intestinal absorption of quinine from solutions containing various amounts of sucrose or sodium carboxymethyl cellulose in the rat. The amount of quinine absorbed from 0-240 min was highest from the hypotonic and isotonic solutions and decreased with increasing osmotic pressure or viscosity. The effect was more marked with osmotic pressure than viscosity. Similar results were obtained on bioavailability. The results were consistent with reports that gastric emptying rate and quinine concentration of the gastric effluent were more markedly reduced by increasing osmotic pressure than by increasing viscosity.