THE EFFECTS OF DIETARY DEFICIENCY OF IODIN UPON THE THYROID AND PARATHYROID GLANDS IN THE RAT

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Abstract
6 Wistar albino rats (3 males and 3 females) were reared from weaning on a very low I diet. A corresponding number of litter-mate controls were reared on the same diet plus an estimated normal I supply. All the rats remained healthy and grew normally, with no significant difference between test rats and controls in food-intake, water-intake, or body weight. Since the weights and usual measurements of the thyroid gland in the rat are considered somewhat unreliable, the more laborious but accurate method of volumetric determinations from serial sections was used. No appreciable enlargement of the gland was found as a result of the low I diet, and no significant difference in histologic structure. Likewise no significant difference was found between the test rats and controls in the size or structure of the parathyroid glands. A sex difference in these glands was confirmed, showing relatively larger size in the female rats.

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