Improving Dissolution Rates of Griseofulivin by Deposition on Disintegrants

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Abstract
The dissolution rate of griseofulvin was markedly enhanced by the solvent deposited on the disintegrants of Primojel, Mobile Starch and Nymcel. The enahancement of the dissolution rate of the solvent deposition systems was due eto the effects of wetting and deaggreation of the disintegrants. The dissolution of the grisefulvin from the Primojel system was at a higher rate than the other systems. This was attributed to the smaller particle size of the griseofulvin in the Primojel system. The tablets of the Primojel system demonstrated the highest dissolution rate. This was resulted form the fast disintegration time of the tablets and the small particle size of the griseofulvin.
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