SPLANCHNIC HEMODYNAMIC FACTORS IN CIRRHOSIS WITH REFRACTORY ASCITES

  • 1 January 1979
    • journal article
    • research article
    • Vol. 93  (2) , 301-309
Abstract
Splanchnic and systemic hemodynamic observations in 8 patients with cirrhosis and refractory ascites were compared to those of 25 patients with [alcoholic] cirrhosis and responsive ascites. The refractory ascitic group was characterized by less portasystemic shunting from both the superior mesenteric and splenic vascular beds, a lower cardiac output a higher systemic vascular resistance, a wider arterial-hepatic venous O2 difference, and a tendency for a lower hepatic blood flow and higher postsinusoidal resistance. Portal pressures assessed from hepatic vein catheterization were similar in the 2 groups. The absence of a well-developed portasystemic collateral bed in patients with refractory ascites could in part be caused by the tense ascites but could also be an important factor in the mechanism of refractory ascites.