C-ALKYLATION OF N-ACETOXY-N-2-ACETYLAMINOFLUORENE - EFFECTS ON ITS REACTION WITH DNA INVITRO
- 1 January 1984
- journal article
- research article
- Vol. 7 (2) , 89-99
Abstract
In vitro reactions of DNA with the carcinogen N-acetoxy-N-2-acetylaminofluorene (N-AcO-AAF), N-acetoxy-7-ethyl-N-2-acetylaminofluorene (N-AcO-EtAAF) and N-acetoxy-7-n-butyl-N-2-acetylaminofluorene (N-AcO-But-AAF) are compared. C-alkylation of N-AcO-AAF affects the reactivity of the metabolite towards DNA. The electronic effect and the size of the alkyl group seem to determine the reactivity of the metabolite. Although the adducts are about the same for the 3 metabolites, the proportion of guanine-C-8 adducts diminishes with an increase in the size of the alkyl group.This publication has 11 references indexed in Scilit:
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