FACTORS AFFECTING THE DEVELOPMENT OF RESISTANCE TO TRAUMATIC SHOCK IN THE RAT

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Abstract
Experiments have been conducted on rats to determine what factors may influence mortality and resistance, which have previously been shown to follow traumatic shock produced by the drum method. The resistant condition followed a single exposure to trauma and developed after a latent period of 24 hr. It lasted for four to six days. The degree of resistance was proportional to the severity of the initial trauma.The percentage mortality following continuous and interrupted trauma was determined. Rest intervals between each 100 turns of the drum allowed greater tolerance to trauma. The amount of trauma required to give 50% mortality was directly related to the length of the rest interval. When this was 15 min., 2500 turns was followed by only 17% mortality.Interrupted trauma was found to be followed by resistance after a latent period of 24 hr. The resistance was not as great as that produced by the same amount of continuous trauma.Attempts to transfer resistance by transfusion of rat serum were not successful nor were other experiments designed to explain the mechanism of resistance.The evidence presented suggests that some toxic substance is produced by trauma. This may either cause the death of the animal, or in 24 hr. lead to a resistance to subsequent trauma.

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