Propafenone disposition kinetics in cardiac arrhythmia

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Abstract
Propafenone disposition kinetics were studied after i.v. oral doses in patients with ventricular arrhythmias. Plasma concentration-time data were fit to a 2-compartment model for all but one patient, whose data required fitting to a 3-compartment model. The model-independent calculated values of clearance, steady-state volume of distribution and terminal t1/2 [half-life] were 11.2 .+-. 4.8 ml/min per kg 3.6 .+-. 2.1 l/kg and 5.0 .+-. 3.6 h. After 5 days on oral propafenone, elimination t1/2 was 6.2 .+-. 3.3 h. The longer t1/2 and the estimates of steady-state bioavailability above 100% suggests that clearance decreases during chronic oral dosing. Considerable intersubject variability was noted in all disposition parameters.

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