Glycopeptide Hormones and Neoplasms

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Abstract
In this issue of the Journal Kahn et al. describe the use of radioimmunoassays for alpha chain, beta chain and intact human chorionic gonadotropin (hCG) to distinguish malignant from benign pancreatic islet--cell neoplasms. To put their observations in perspective, the reader must be aware of the immense progress in the biochemistry of glycopeptide hormones that has occurred in the last 10 years.1 2 3 4 5 6 7 These hormones include hCG, pituitary luteinizing hormone (LH), follicle-stimulating hormone (FSH) and thyroid-stimulating hormone (TSH). Each is composed of an alpha peptide chain and a beta peptide chain. The alpha chains of LH, FSH and TSH are identical . . .