SIGNIFICANCE OF IMPRINT CYTOLOGY IN BREAST BIOPSY DIAGNOSIS

  • 1 January 1978
    • journal article
    • research article
    • Vol. 22  (3) , 133-137
Abstract
Tissue biopsies of the breast with and without carcinomas were examined simultaneously by intraoperative histology and imprint cytology. In 95% of the cases there was a good agreement between the histologic and cytologic diagnoses. The reliability of the imprint cytology was tested in some complicated cases such as proliferating fibroadenomas, pseudoinvasive adenosis and carcinomas. In 20.2% of the cases with carcinoma, the tumor cells showed peculiar intracytoplasmic inclusions, whereas such inclusions were found only in 0.43% of the biopsies of mammas without carcinoma. Their morphological variations and the histochemical pattern were discussed. Simultaneous cytologic examination of unfixed mamma biopsies can be a good screening method; the intracytoplasmic inclusions may be an especially helpful histopathologic feature in the diagnosis of breast cancer.

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