Proposed modifications to metabolic model for glycogen‐accumulating organisms under anaerobic conditions

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Abstract
Filipe et al. (2001) proposed an anaerobic metabolic model for glycogen‐accumulating organisms (GAO) in which the succinate–propionate pathway was used to describe the production of propionyl‐CoA. However, propionyl‐CoA is only an intermediate product in the above pathway. Stopping at propionyl‐CoA instead of propionate (the end product of the pathway) results in the consumption of one ATP from succinate to succinyl‐CoA, which was not accounted for in the model of Filipe et al. (2001). This resulted in significant errors in the stoichiometric coefficients in the final metabolic model. A modified model is presented in this communication and is shown to fit the experimental data significantly better than the original model. © 2002 Wiley Periodicals, Inc. Biotechnol Bioeng 80: 277–279, 2002.