Infants of Depressed Mothers Exhibit Atypical Frontal Brain Activity A Replication and Extension of Previous Findings

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Abstract
The left frontal brain region is specialized for expression of positive emotions (e.g. joy) whereas the right frontal region is specialized for ncgative emotions (e.g, sadness). Depressed adults have been found to exhibit redeed left frontal electroencephalographic-activity. In this study, baseline frontal and parietal EEG activity was measured in l3–l5-month-old infants of depressed and nondepressed mothers who were of middle income with no other major psychiatric problems. Compared lo infants of nondepressed mothers, infants of depressed mothers exhibited reduced left frontal EEG activity. Infants of mothers with major depression exhibited lower levels of left frontal EEG activity than those of mothers with subthreshold depression.