INFLUENCE OF HYPOPHYSECTOMY ON GLUCONEOGENESIS IN THE NORMAL AND DEPANCREATIZED DOG

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Abstract
It is concluded that the metabolic disturbance following hypophysectomy, whether in the otherwise normal or in the depancreatized dog, is not due to an altered capacity to utilize carbohydrate but is rather the result of a defect in the mechanism of the new formation of sugar from non-carbohydrate precursors. The hypophysectomized animal differs from the normal in that the latter derives sugar from both protein and fat, while the former is unable to convert the fat. This hypothesis accounts for: The hypoglycemic effect of fasting in the hypophysectomized dog; the fact that protein (or carbohydrate) feeding maintains the blood sugar level of the hypophysectomized dog and alleviates the hypoglycemia of fasting, while fat is inert in both respects; the persistence of the hypoglycemic effect of fasting in the hypophysectomized animal even after pancreatectomy; the milder form of diabetes in the adequately fed hypophysectomized-depancreatized animal as compared to the depancreatized animal; the lack of ketonuria without regard to the degree of hyperglycemia and glycosuria in the hypophysectomized-depancreatized animal.

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