RAPID AND MILD SYNTHESES OF RADIOIODINE-LABELED RADIOPHARMACEUTICALS

  • 1 January 1981
    • journal article
    • research article
    • Vol. 22  (10) , 908-912
Abstract
Radioiodine-labeled pharmaceuticals have been used extensively in diagnostic nuclear medicine. A rapid and mild method for incorporating radioiodine into functionally substituted molecules was developed. The new process involves the reaction of the radioiodide ion with organoboranes in the presence of gentle oxidizing reagents. The radioiodide is utilized nearly quantitatively in a matter of seconds. The radiochemical yields are excellent, and parallel those obtained when ICl is reacted with organoboranes.