Antioxidant role of melatonin in lipid peroxidation of human LDL
Open Access
- 18 August 1997
- journal article
- Published by Wiley in FEBS Letters
- Vol. 413 (2) , 289-293
- https://doi.org/10.1016/s0014-5793(97)00918-6
Abstract
It is concluded that melatonin is not incorporated into LDL in sufficient concentrations to prevent lipid peroxidation effectively. When melatonin is present in the incubation medium during oxidation, a partitioning equilibrium between aqueous and lipid phase is established. Only under these conditions can melatonin act as a chain breaking antioxidant. The concentrations required, however, are far beyond those found in human plasma. Therefore, the data in this study do not support a direct physiological relevance of melatonin as an antioxidant in lipid peroxidation processes.Keywords
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