Ultrastructural identification of Ia positive dendritic cells in the lactating rat mammary gland
- 1 January 1985
- journal article
- research article
- Published by Springer Nature in Virchows Archiv
- Vol. 406 (1) , 17-25
- https://doi.org/10.1007/bf00710553
Abstract
Dendritic cells which express Ia antigen have been demonstrated for the first time in the lactating rat mammary gland. Ultrastructurally, the dendritic cells appear as electron-lucent pale cells interspersed among the epithelial cells of the alveoli, forming a cell population distinct from classical macrophages. They show morphological resemblance to the dendritic cells of lymphoid organs as well as the Langerhans cells of skin. The Ia antigen has been localised by electron microscopic immunocytochemistry on the cell membrane and endocytotic vesicles and tubules. Ia positive cells are also seen in the stroma of the mammary gland. It is proposed that the dendritic cells of the mammary gland belong to the lineage of epidermal Langerhans cells and lymphoid dendritic cells, subserving an immunological role in the lactating breast.This publication has 24 references indexed in Scilit:
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