In vitro Study on the Effects of Silver Sulfadiazine on Bilirubin Binding

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Abstract
Silver sulfadiazine is a new topical antimicrobial agent with a broad spectrum of activity against most bacterial (both gram-positive and gram-negative) and many fungal species. This broad spectrum of activity suggests that silver sulfadiazine may be useful in clinical situations which require the inhibition of cutaneous bacterial and/or fungal colonization. The present study was undertaken to determine the effect of this agent on bilirubin-protein binding. Using chromatographic procedures on artificially jaundiced sera and human serum albumin solutions, we were unable to detect any release of protein-bound bilirubin by a saturated suspension of silver sulfadiazine.

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