Inhibition of head and neck metastatic and/or recurrent cancer by local administration of multi-cytokine inducer OK-432
- 1 January 1996
- journal article
- research article
- Published by Cambridge University Press (CUP) in The Journal of Laryngology & Otology
- Vol. 110 (5) , 449-453
- https://doi.org/10.1017/s0022215100133948
Abstract
The multi-cytokine inducer OK-432 is a pulverized preparation of the low-virulence SU strain of Streptococcus pyogenes of human origin. A reduction of the tumour mass in the OK-432-injected areas was observed in 11 out of 13 patients with metastatic and/or recurrent head and neck cancer. Complete response (CR), partial response (PR) and minor response (MR) were noted in six, three and two cases respectively. OK-432 local administration therapy could create a new strategy for cancer therapy.Keywords
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