The relative frequencies of HLA‐A*10 alleles in five major United States ethnic populations

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Abstract
The frequency of each A*10 allele was determined in 5 major United States ethnic populations randomly selected from a pool containing 82,979 unrelated individuals. The phenotype frequency of A10 was 10.5% in Caucasians, 14.0% in African‐Americans, 21.1% in Asians/Pacific Islanders, 10.6% in Hispanics, and 9.8% in Native Americans. Fifty‐nine individuals who had at least one A10 antigen were randomly chosen from each ethnic group for polymerase chain reaction using sequence‐specific oligonucleotide probes (PCR‐SSOP) typing. Thirteen of sixteen known A10 alleles were identified in this pool. The most common alleles observed were: A*2601 in Caucasians (55%), Hispanics (58%), and Native Americans (45%); A*3402 in African‐Americans (34%); and A*3401 in Asians/Pacific Islanders (61%). The African‐American and Asian/Pacific Islander populations differ from all other populations in the distribution of A*10 alleles, particularly, A*2601, A*3401, and A*3402.