INFLUENCE OF ALPHA-THIOGLYCEROL ON ERYTHROPOIESIS IN FETAL MOUSE-LIVER CELL-CULTURES

  • 1 January 1977
    • journal article
    • research article
    • Vol. 27  (5) , 185-187
Abstract
.alpha.-Thioglycerol can increase Hb synthesis in suspension cultures of fetal mouse liver cells. The mechanism of this effect is unknown but appears to be directly on S-phase cells increasing their sensitivity to erythropoietin. .alpha.-Thioglycerol inhibits heme synthesis when S-phase cells were removed by prior treatment with hydroxyurea. The stimulatory or inhibitory effects of thiols depending on the proportion of cells in S-phase suggests that extreme caution should be used when interpreting cell kinetic studies of cultured cells if thiols are present in the cultures.

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