Preferential mutagenesis at G·C base pairs by theanti 3,4-dihydrodiol 1,2-epoxide of 7-methylbenz[a]anthracene
- 1 January 1991
- journal article
- Published by Wiley in Molecular Carcinogenesis
- Vol. 4 (3) , 176-179
- https://doi.org/10.1002/mc.2940040303
Abstract
The racemic anti‐dihydrodiol epoxide of 7‐methylbenz[a]anthracene preferentially induced mutations at G·C base pairs in the pS 189 shuttle vector. Mutations were not randomly distributed throughout the supF target gene, but were concentrated at five hotspots. The hotspots for this agent did not correspond exactly to those produced by any other dihydrodiol epoxide examined to date, indicating that dihydrodiol epoxide structure and reactivity play a major role in determining mutagenic hotspots.Keywords
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