NONRANDOMNESS IN THE DISTRIBUTION OF CHROMOSOME ABERRATIONS INDUCED BY A RADIOMIMETIC CHEMICAL, 4-NITROQUINOLINE 1-OXIDE, IN TUMOR CELLS

Abstract
The chromosomal aberrations in Yoshida sarcoma cells induced by a radiomimetic agent, 4-nitroquinoline 1-oxide, were of chromatid type. The distribution of chromatid intrachanges (breakages and translocations) among the cells was nonrandom. Frequency of the breakages in each chromosome group was not proportional to the length of metaphase chromosome. The aberrations were observed adjacent to the secondary constriction.