Nucleotide sequence of an HLA-DQ alpha chain derived from a DRw9 cell line: genetic and evolutionary implications.

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Abstract
Three families of human Ia molecules, DP, DQ and DR, have previously been defined. A c[complementary]DNA clone, pDSH-9.1, encoding the .alpha. chain of a DQ molecule derived from an HLA-DRw9 homozygous cell line was isolated and sequenced. Comparison of the nucleotide and predicted protein sequence to those of other DQ-.alpha. subunits reveals that DQ-.alpha. subunits derived from DR4, -7 and -9 cells are very similar to each other but quite different from a DQ-.alpha. subunit derived from a DRw6 cell line. Certain Ia haplotypes may have a common evolutionary history. In the context of current serologic and biochemical knowledge, it appears that the gene encoding the DQ-.alpha. subunit is in strong linkage disequilibrium with the DR locus.