Immunofluorescence Studies Indicate that the Basic Trypsin-Kallikrein-Inhibitor of Bovine Organs (Trasylol) Originates from Mast Cells

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Abstract
Using the indirect immunofluorescence technique, the basic kallikrein EC (EC 3.4.21.8)-trypsin (EC 3.4.21.4) inhibitor of bovine organs, Trasylol, could be localized in tissue mast cells of bovine lung, liver, pancreas and parotid gland. Identification of cells exhibiting specific fluorescence as tissue mast cells was achieved by combined light microscopy and WM diagnosis of bovine liver tissue sections. The presence of Trasylol in mast cells explains the widespread distribution of this inhibitor in functionally totally different organs or tissues of the bovine organism, as determined earlier by biochemical means. Identification of Trasylol as a mast cell constituent will facilitate the search for the biological function of this inhibitory protein in connection with a unique and highly specialized cell population.

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