Transforming growth factor J3 type II receptor (TGFpRII) mutation in gastric lymphoma without mutator phenotype
- 1 February 1998
- journal article
- Published by Wiley in Pathology International
- Vol. 48 (2) , 134-137
- https://doi.org/10.1111/j.1440-1827.1998.tb03882.x
Abstract
A new mutation in the serine‐threonine klnase domain of the transforming growth factor β type II receptor (TGFpRII) was found in a case of diffuse, B cell non‐Hodgkin's lymphoma of the stomach. A mfssense mutation (ACA to GCA, Thr to Ala) was detected In exon 5, and a wild type allele was also present. This Is the first naturally occurring mutation in the klnase domain of this gene identified in human primary lymphoma. The replication error at three loci was negative, and the poly A tract of exon 3, which is frequently a target of mismatch repair genes, was intact. Malignant lymphoma of B cell origin in the stomach Is an addition to an expanding catalogue of tumors with TGFβRII alterations, and the biological sequelae of the change in the functional domain and the clinical characteristics of the patient in this study are intriguing.Keywords
This publication has 11 references indexed in Scilit:
- Infrequent mutations of the transforming growth factor beta-type II receptor gene at chromosome 3p22 in human lung cancers with chromosome 3p deletions.Carcinogenesis: Integrative Cancer Research, 1997
- Mutation analysis of coding sequences of the entire transforming growth factor beta type II receptor gene in sporadic human colon cancer using genomic DNA and Intron primersOncogene, 1997
- The Genomic Structure of the Gene Encoding the Human Transforming Growth Factor β Type II Receptor (TGF-β RII)Genomics, 1996
- Mutations of the Transforming Growth Factor-β Type II Receptor Gene and Genomic Instability in Hereditary Nonpolyposis Colorectal CancerBiochemical and Biophysical Research Communications, 1995
- Frequent co-occurrence of mutator phenotype in synchronous, independent multiple cancers of the stomachCarcinogenesis: Integrative Cancer Research, 1995
- Overexpression of human cyclin D1 reduces the transforming growth factor beta (TGF-beta) type II receptor and growth inhibition by TGF-beta 1 in an immortalized human esophageal epithelial cell line.Proceedings of the National Academy of Sciences, 1994
- Loss of receptors for transforming growth factor beta in human T-cell malignancies.Proceedings of the National Academy of Sciences, 1994
- Stepwise Participation of p53 Gene Mutation During Dedifferentiation of Human Thyroid CarcinomasDiagnostic Molecular Pathology, 1994
- Alteration of immunoreactivity by hydrated autoclaving, microwave treatment, and simple heating of paraffin‐embedded tissue sectionsAPMIS, 1994