BIOTRANSFORMATION OF THE CARCINOGEN CHRYSAZIN BY NADPH-MICROSOME SYSTEM
- 1 November 1986
- journal article
- research article
- Vol. 54 (2) , 217-226
Abstract
The interactions of chrysazin, a carcinogenic anthraquinone, with electron transport systems in microsomes and mitochondria (submitochondrial particles, SMP) were studied. The NADPH-dependent oxygen uptake in microsomes was significantly enhanced by chrysazin and no such effect was observed in the NADH-dependent reactions in microsomes and SMP. The NADPH-microsome system caused a marked alteration in the visible absorption spectrum of chrysazin. These results strongly suggest that chrysazin is biotransformed selectively by the NADPH-microsome system.This publication has 16 references indexed in Scilit:
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