THE ORGAN CULTURE OF ADULT HUMAN ARTICULAR CARTILAGE, FROM PATIENTS WITH OSTEOARTHROSIS

1 May 1976

journal article
research article
Published by Oxford University Press (OUP) in Rheumatology

Vol. 15 (2) , 116-122
https://doi.org/10.1093/rheumatology/15.2.116

Abstract

Adult human articular cartilage has been maintained in organ culture for three days. The uptake of ³⁵SO₄ has been studied over a 48-hour period. The incorporation of ³⁵SO₄ was significantly increased in osteoarthrotic cartilage compared to normal cartilage from the same joints. The uronic acid content of the osteoarthrotic cartilage was significantly reduced which reflects the proteoglycan loss in the diseased tissue. The DNA content, which is an indirect measurement of the cell population, was not significantly different in the diseased and normal cartilage.

Keywords

ARTICULAR CARTILAGE
35SO4
URONIC
ADULT HUMAN
OSTEOARTHROTIC
ORGAN CULTURE
HUMAN ARTICULAR

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