Thermosensory activation of insular cortex
Top Cited Papers
Open Access
- 1 February 2000
- journal article
- clinical trial
- Published by Springer Nature in Nature Neuroscience
- Vol. 3 (2) , 184-190
- https://doi.org/10.1038/72131
Abstract
Temperature sensation is regarded as a submodality of touch, but evidence suggests involvement of insular cortex rather than parietal somatosensory cortices. Using positron emission tomography (PET), we found contralateral activity correlated with graded cooling stimuli only in the dorsal margin of the middle/posterior insula in humans. This corresponds to the thermoreceptive- and nociceptive-specific lamina I spinothalamocortical pathway in monkeys, and can be considered an enteroceptive area within limbic sensory cortex. Because lesions at this site can produce the post-stroke central pain syndrome, this finding supports the proposal that central pain results from loss of the normal inhibition of pain by cold. Notably, perceived thermal intensity was well correlated with activation in the right (ipsilateral) anterior insular and orbitofrontal cortices.Keywords
This publication has 40 references indexed in Scilit:
- Dissociating Pain from Its Anticipation in the Human BrainScience, 1999
- A distinct thermoreceptive subregion of lamina I in nucleus caudalis of the owl monkeyJournal of Comparative Neurology, 1999
- Nociceptive and thermoreceptive lamina I neurons are anatomically distinctNature Neuroscience, 1998
- The Thermal Grill Illusion: Unmasking the Burn of Cold PainScience, 1994
- A Three-Dimensional Statistical Analysis for CBF Activation Studies in Human BrainJournal of Cerebral Blood Flow & Metabolism, 1992
- Rapid Automated Algorithm for Aligning and Reslicing PET ImagesJournal of Computer Assisted Tomography, 1992
- Central post-stroke pain — a study of the mechanisms through analyses of the sensory abnormalitiesPain, 1989
- The nucleus of the solitary tract in the monkey: Projections to the thalamus and brain stem nucleiJournal of Comparative Neurology, 1980
- Perceived intensity of peripheral thermal stimuli is independent of internal body temperature.Journal of Comparative and Physiological Psychology, 1976
- SENSORY DISTURBANCES FROM CEREBRAL LESIONSBrain, 1911