A PLETHYSMOGRAPHIC STUDY OF CHANGES IN THE VOLUME OF THE LIVER IN THE INTACT ANIMAL

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Abstract
The literature of changes in the volume of the liver in anesthetized animals is summarized. A method is described whereby changes in the volume of the liver may be recorded in the intact dog. A lobe of liver is exposed through a thoraco-abdominal incision and is enveloped in a collodion plethysmograph. Changes in the volume of the liver synchronous with the pulse were observed. Increases were recorded during inspiration and decreases during expiration. A slight increase and then a more pronounced decrease directly followed excitation such as sudden sound. Decreases in the volume of the liver were recordedfollowing inhalation of amyl nitrite and injection of epinephrin. Increases were recorded after the injection of glucose and were greater than that caused by injection of an equal amount of isotonic saline. An initial decrease, then a marked increase in the volume of the liver, followed injection of peptone. An increase in the volume of the liver was recorded in rebreathing. Intravenous injection of synthalin caused a decrease in the volume of the liver, as did inhalation of chloroform. Rapid increases in the volume of the liver were recorded during vomiting.

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