Evidence for Genetic Hitchhiking Effect Associated With Insecticide Resistance in Aedes aegypti
Open Access
- 1 February 1998
- journal article
- research article
- Published by Oxford University Press (OUP) in Genetics
- Vol. 148 (2) , 793-800
- https://doi.org/10.1093/genetics/148.2.793
Abstract
Information on genetic variation within and between populations is critical for understanding the evolutionary history of mosquito populations and disease epidemiology. Previous studies with Drosophila suggest that genetic variation of selectively neutral loci in a large fraction of genome may be constrained by fixation of advantageous mutations associated with hitchhiking effect. This study examined restriction fragment length polymorphisms of four natural Aedes aegypti mosquito populations from Trinidad and Tobago, at 16 loci. These populations have been subjected to organophosphate (OP) insecticide treatments for more than two decades, while dichlor-diphenyltrichlor (DDT) was the insecticide of choice prior to this period. We predicted that genes closely linked to the OP target loci would exhibit reduced genetic variation as a result of the hitchhiking effect associated with intensive OP insecticide selection. We also predicted that genetic variability of the genes conferring resistance to DDT and loci near the target site would be similar to other unlinked loci. As predicted, reduced genetic variation was found for loci in the general chromosomal region of a putative OP target site, and these loci generally exhibited larger FST values than other random loci. In contrast, the gene conferring resistance to DDT and its linked loci show polymorphisms and genetic differentiation similar to other random loci. The reduced genetic variability and apparent gene deletion in some regions of chromosome 1 likely reflect the hitchhiking effect associated with OP insecticide selection.Keywords
This publication has 40 references indexed in Scilit:
- Population genetics with RAPD-PCR markers: the breeding structure of Aedes aegypti in Puerto RicoHeredity, 1996
- MOLECULAR EVIDENCE FOR NATURAL SELECTIONAnnual Review of Ecology and Systematics, 1995
- Chromosomal mapping of two loci affecting filarial worm susceptibility in Aedes aegyptiInsect Molecular Biology, 1994
- Why is the genome variable? Insights from DrosophilaTrends in Genetics, 1992
- Levels of naturally occurring DNA polymorphism correlate with recombination rates in D. melanogasterNature, 1992
- Worldwide migration of amplified insecticide resistance genes in mosquitoesNature, 1991
- A salivary gland-specific, maltase-like gene of the vector mosquito, Aedes aegyptiGene, 1989
- Genome evolution in mosquitoes: intraspecific and interspecific variation in repetitive DNA amounts and organizationGenetics Research, 1988
- Gene Flow in Natural PopulationsAnnual Review of Ecology and Systematics, 1985
- Genetics and the Origin of a Vector Population: Aedes aegypti , a Case StudyScience, 1980