Synthesis of buf-20(21)-enolides and bufa-20,22-dienolides

Abstract
A practical three-step procedure for converting an aldehyde to a 5-substituted dihydro-2-pyrone or by an additional step to the corresponding 2-pyrone has been summarized. Synthesis of 2-pyrone 5, buf-20(21)-enolide 9 (and Δ5-derivative) and bufadienolide 10 were used for illustration.

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