BDNF is essential to promote persistence of long-term memory storage
Top Cited Papers
- 19 February 2008
- journal article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 105 (7) , 2711-2716
- https://doi.org/10.1073/pnas.0711863105
Abstract
Persistence is a characteristic attribute of long-term memories (LTMs). However, little is known about the molecular mechanisms that mediate this process. We recently showed that persistence of LTM requires a late protein synthesis- and BDNF-dependent phase in the hippocampus. Here, we show that intrahippocampal delivery of BDNF reverses the deficit in memory persistence caused by inhibition of hippocampal protein synthesis. Importantly, we demonstrate that BDNF induces memory persistence by itself, transforming a nonlasting LTM trace into a persistent one in an ERK-dependent manner. Thus, BDNF is not only necessary, but sufficient to induce a late postacquisition phase in the hippocampus essential for persistence of LTM storage.Keywords
This publication has 36 references indexed in Scilit:
- Protracted Synaptogenesis after Activity-Dependent Spinogenesis in Hippocampal NeuronsJournal of Neuroscience, 2007
- Long-term potentiation and memoryPhilosophical Transactions Of The Royal Society B-Biological Sciences, 2003
- Brain-Derived Neurotrophic Factor/TrkB Signaling in Memory ProcessesJournal of Pharmacological Sciences, 2003
- From Acquisition to Consolidation: On the Role of Brain-Derived Neurotrophic Factor Signaling in Hippocampal-Dependent LearningLearning & Memory, 2002
- BDNF–triggered events in the rat hippocampus are required for both short‐ and long‐term memory formationHippocampus, 2002
- Some Forms of cAMP-Mediated Long-Lasting Potentiation Are Associated with Release of BDNF and Nuclear Translocation of Phospho-MAP KinaseNeuron, 2001
- BDNF Enhances Quantal Neurotransmitter Release and Increases the Number of Docked Vesicles at the Active Zones of Hippocampal Excitatory SynapsesJournal of Neuroscience, 2001
- Fornix-Dependent Induction of Hippocampal CCAAT Enhancer-Binding Protein β and δ Co-Localizes with Phosphorylated cAMP Response Element-Binding Protein and Accompanies Long-Term Memory ConsolidationJournal of Neuroscience, 2001
- The neurotrophin hypothesis for synaptic plasticityTrends in Neurosciences, 2000
- Memory--a Century of ConsolidationScience, 2000