REACTIVITY OF THE UTERUS TO PRE-SACRAL NERVE STIMULATION AND TO EPINEPHRINE, PITUITRIN AND PILOCARPINE ADMINISTRATION DURING CERTAIN SEXUAL STATES IN THE ANESTHETIZED RABBIT

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Abstract
Of 23 virgin rabbits (1.6-3.6 kgm. in wt.) 8 were castrated, and 4 of these injected with estrin; others were injected with prolan and the uterus exposed on the 2d, 6th and 7th, 11th and 12th days of pseudopregnancy. Negligible en-dometrial proliferation appeared in 4 others used on the 18th day of continued luteal activity, sustained with prolan. Dial (Ciba) was used intramusc. 11/2-2 hrs. before exp. Uterine contractions were recorded by a lead taken directly from the uterus by a thread running to a lever. Epinephrine, 0.1-0.2 cc. 1/10,000; pilocarpine 0.01 grain; and 0.1-0.2 units of pituitrin were used. Only pilocarpine depended on the presence of estrin for a contraction; the atrophied uteri of castrates responded to the other modes of stimulation. During pseudopregnancy, a "pregnancy-reversal" was obtained (no uterine contraction) on the 2d and 6th and 7th days. By the 11th day, responses to all but pilocarpine were regularly obtained, indicating waning of luteal function, as regards inhibition of re activity. After 18 days of luteal activity the "pregnancy-reversal" persisted without significant endometrial proliferation, indicating sustained luteal function as regards reactivity, but not as regards proliferation. Since crystalline progestin affects both reactions, failure of endometrial proliferation lies within the endometrium and not in lutein hormone dysfunction.

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