Pathogenesis of Osler's Nodes

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Abstract
Four patients in whom endocarditis was verified at autopsy had the pathogenic organism isolated from aspirates of Osler''s nodes. In 3 cases the responsible organism was identified in Gram stains made from aspirates. The etiologic agent was Staphylococcus aureus in 3 cases and Candida albicans in 1 case. Histologic examination of an Osler''s node from 1 patient with S. aureus endocarditis showed a microabscess in the papillary dermis and microemboli in nearby dermal arterioles. Osler''s skin lesions are in all probability caused by minute emboli and not perivasculitis resulting from an immune reaction to the pathogenic organism.
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