THE EFFECTS OF IRRITANTS AND THYROXIN ON HAIR GROWTH IN ALBINO RATS

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Abstract
When increased vascularifcation and edema of the skin of underfed rats Were created by daily external applications of cantharides, capsicum, xylene, or benzoic acid, the quiescent hair follicles became active and produced hair externally 10 to 14 days after the beginning of the applications. Daily subcut. injs. of 0.5 cc. of 0.3% histamine soln. were equally as effective. Subcut. injs. of 02 mg. of thyroxin daily for 3 days in underfed rats caused the hair to appear externally about 9 days after the initial inj. External applications 0f irritants simultane-ously with injs. of thyroxin induced hair growth usually a day sooner than the thyroxin alone. By dissolving thyroxin in the irritants and applying them daily for many days, hair appeared externally about 10 days after the first application.

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