Indirect Ultraviolet Visualization and Quantitation of Methenamine with Reversed Phase Ion Pairing Liquid Chromatography

Abstract
Indirect UV visualization of a polycyclic polyamine, methenamine, a urinary antibacterial agent, is reported for the 1st time. The ability to detect a non-UV active compound quantitatively using a UV monitor is demonstrated; the optimized experimental conditions are discussed. The calibration curve obtained was linear over 2 orders of magnitude extending to a detection limit of 250 pmol.