Dissolution Behaviour of Acetaminophen from Powder and Tablets of Ground Mixture of Acetaminophen with Florite RE and Polyethylene Glycol 6000.
- 1 January 1995
- journal article
- Published by Japanese Society of Pharmaceutical Health Care and Sciences in Japanese Journal of Hospital Pharmacy
- Vol. 21 (1) , 1-8
- https://doi.org/10.5649/jjphcs1975.21.1
Abstract
Ground mixtures of Florae®, RE (FR) (porous calcium silicate) and acetaminophen (ACTA) were prepared in order to improve the dissolution and compression characteristics of ACTA. No diffraction peaks due to ACTA crystals were observed in the powder X-ray diffraction pattern of the ground mixture with FR (FR: ACTA=9: 1), which showed amorphization of ACTA crystals caused by grinding. The ground mixture produced an improved dissolution of ACTA in comparison with the ACTA crystals, and the tablets prepared from the ground mixture showed faster dissolution behaviour of ACTA than the tablets prepared from a physical mixture. Tablets of ternary ground mixture containing FR, ACTA and polyethylene glycol 6000 (PEG 6000) were prepared. The dissolution profile of ACTA from the tablet was found to be controlled by the PEG6000 content and compression pressure.Keywords
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