The evaluation of HBDH and LDH isoenzymes in cardiac cell necrosis of the rat
- 1 August 1988
- journal article
- research article
- Published by Wiley in Journal of Applied Toxicology
- Vol. 8 (4) , 233-238
- https://doi.org/10.1002/jat.2550080402
Abstract
The total LDH, HBDH and LDH isoenzyme activities were assessed in a number of rat tissues. HBDH did not correlate with LD1 and LD2 isoenzyme activity in tissues with high HBDH activity. HBDH therefore cannot be used as a marker for cardiac necrosis in the rat. In rats treated with isoprenaline and SK&F 94120 at doses producing myocardial necrosis, only the LD1 isoenzymes showed any significant change but only within the first 24 h of treatment. No statistically significant differences were seen in the plasma AST, CK, CK‐MB and total LDH activities.Keywords
This publication has 6 references indexed in Scilit:
- Pharmacological studies with SK&F 94120, a novel positive inotropic agent with vasodilator activityJournal of Pharmacy and Pharmacology, 1986
- Catecholamine cardiotoxicityJournal of Molecular and Cellular Cardiology, 1985
- The tissue activities of some diagnostic enzymes in ten mammalian speciesJournal of Comparative Pathology, 1978
- Patterns of lactate dehydrogenase isoenzymes during gonadogensis in the ratReproduction, 1978
- IsoenzymesPublished by Springer Nature ,1970
- CHEMICAL DIFFERENCES BETWEEN MULTIPLE FORMS OF LACTIC ACID DEHYDROGENASES*Annals of the New York Academy of Sciences, 1961