Expression of a high-affinity mechanism for acquisition of transferrin iron by Neisseria meningitidis

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Abstract
Iron-starved meningococci grown at either pH 7.2 or 6.6 were capable of removing and incorporating iron from human transferrin by a saturable, cell surface mechanism that specifically recognized transferrin rather than iron. The maximum expression of the iron uptake system occurred after 4 h of iron starvation. The uptake of the iron was dependent upon a functioning electron transport chain and was sensitive to 60 degrees C and trypsin. Cells grown under iron-sufficient conditions were incapable of accumulating iron from transferrin. No evidence was found for a primary role for cell-free soluble siderophores in the removal of iron from transferrin. The nonpathogenic neisseriae, Neisseria flava and N. sicca, were unable to utilize iron on transferrin.

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