Protective Tumor Immunity Induced by Potassium Chloride Extracts of Guinea Pig Hepatomas
- 1 June 1975
- journal article
- research article
- Published by Oxford University Press (OUP) in JNCI Journal of the National Cancer Institute
- Vol. 54 (6) , 1349-1354
- https://doi.org/10.1093/jnci/54.6.1349
Abstract
Tumor-specific antigens of cells of diethylnitrosamine-induced hepatomas in strain-2 guinea pigs were extracted with 3 M KCI. Immunization of normal animals with the extracted tumor antigens in adjuvant protected them against a subsequent challenge with viable tumor cells. Extracted tumor-specific antigens were less effective immunogens than viable tumor cells for both of two antigenically distinct lines.Keywords
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