THE EFFECT OF ANOXIC AND ANEMIC ANOXIA ON THE LEUCOCYTE COUNT

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Abstract
The effect of anoxic and anemic anoxia is studied on the blood picture of normal and adreno-demedullated rats. Anoxic anoxia induced by exposure of the animals to a barometric pressure of 400 mm. Hg for 12 hrs. on 4 successive days causes a leucocytosis after the 1st or 2d period of anoxia in normal but not in adreno-demedullated rats. Similarly, it is observed that CO poisoning induced by the intraperit. inj. of ml. CO/20 g. body wt. and hemorrhage (removal of 1/3 of total blood volume) are followed by a leucocytosis confined to the normal group. The leucocytosis is in all cases of a neu-trophilic character. The expts. indicate that the leucocytosis in anoxic and anemic anoxia is due to a discharge of adrenalin following the excitation of the sympathetico-adrenal system. It is assumed that the liberated adrenalin acts directly on the bone marrow.

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